Acetylcholinesterase: From 3D structure to function
نویسندگان
چکیده
منابع مشابه
Acetylcholinesterase: from 3D structure to function.
By rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase terminates neurotransmission at cholinergic synapses. Acetylcholinesterase is a very fast enzyme, functioning at a rate approaching that of a diffusion-controlled reaction. The powerful toxicity of organophosphate poisons is attributed primarily to their potent inhibition of acetylcholinesterase. Acetylcholinestera...
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In accordance with its biological role, termination of neurotransmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase is one of nature's most efficient enzymes. Solution of its three-dimensional structure revealed that its active site is located at the bottom of a deep and narrow gorge. Such an architecture was unanticipated in view of...
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ژورنال
عنوان ژورنال: Chemico-Biological Interactions
سال: 2010
ISSN: 0009-2797
DOI: 10.1016/j.cbi.2010.01.042